Association of Reperfusion After Thrombolysis With Clinical Outcome Across the 4.5-to 9-Hours and Wake-Up Stroke Time Window A Meta-Analysis of the EXTEND and EPITHET Randomized Clinical Trials

- Campbell, Bruce C. V., Ma, Henry, Desmond, Patricia M., Wijeratne, Tissa, Curtze, Sami, Barber, P. Alan, De Silva, Deidre A., Thijs, Vincent, Levi, Christopher R., Bladin, Christopher F., Sharma, Gagan, Bivard, Andrew, Parsons, Mark W., Donnan, Geoffrey A., Davis, Stephen M., Churilov, Leonid, Yassi, Nawaf, Kleinig, Timothy J., Hsu, Chung Y., Dewey, Helen M., Butcher, Kenneth S., Yan, Bernard

Extending thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

- Campbell, Bruce C. V., Ma, Henry, Ringleb, Peter A., Parsons, MW, Churilov, Leonid, Bendszus, Martin, Levi, Christopher R., Hsu, Chung, Kleinig, Timothy J., Fatar, Marc, Leys, Didier, Molina, Carlos, Wijeratne, Tissa, Curtze, Sami, Dewey, Helen M., Barber, P. Alan, Butcher, Kenneth S., De Silva, Deidre A., Bladin, Christopher F., Yassi, Nawaf

Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation

- Tu, Hans T. H., Campbell, Bruce C. V., Straka, Matus, Bammer, Roland, Albers, Gregory W., Donnan, Geoffrey A., Davis, Stephen M., EPITHET-DEFUSE Investigators,, Christensen, Soren, Desmond, Patricia M., De Silva, Deidre A., Parsons, Mark W., Churilov, Leonid, Lansberg, Maarten G., Mlynash, Michael, Olivot, Jean-Marc

Advanced imaging improves prediction of hemorrhage after stroke thrombolysis

- Campbell, Bruce C. V., Christensen, Søren, Mlynash, Michael, Olivot, Jean-Marc, Straka, Matus, Bammer, Roland, Albers, Gregory W., Donnan, Geoffrey A., Davis, Stephen M., Parsons, Mark W., Churilov, Leonid, Desmond, Patricia M., Barber, P. Alan, Butcher, Kenneth S., Levi, Christopher R., De Silva, Deidre A., Lansberg, Maarten G.

EPITHET: positive result after reanalysis using baseline diffusion-weighted imaging/perfusion-weighted imaging co-registration

- Nagakane, Yoshinari, Christensen, Soren, Bladin, Christopher F., De Silva, Deidre A., Fink, John, Kimber, Thomas E., Schultz, David W., Muir, Keith W., Tress, Brian M., Desmond, Patricia M., Davis, Stephen M., Donnan, Geoffrey A., Brekenfeld, Caspar, EPITHET Investigators,, Ma, Henry, Churilov, Leonid, Parsons, Mark W., Levi, Christopher R., Butcher, Kenneth S., Peeters, Andre, Barber, Alan

Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation

- Campbell, Bruce C. V., Costello, Craig, Lansberg, Maarten G., Mlynash, Michael, Olivot, Jean-Marc, Straka, Matus, Bammer, Roland, Albers, Gregory W., Donnan, Geoffrey A., Davis, Stephen M., Christensen, Soren, Ebinger, Martin, Parsons, Mark W., Desmond, Patricia M., Barber, P. Alan, Butcher, Kenneth S., Levi, Christopher R., De Silva, Deidre A.

Pathophysiological determinants of worse stroke outcome in atrial fibrillation

- Tu, Hans T. H., Campbell, Bruce C. V., Bladin, Christopher F., Donnan, Geoffrey A., Davis, Stephen M., Christensen, Soren, Collins, Marnie, De Silva, Deidre A., Butcher, Kenneth S., Parsons, Mark W., Desmond, Patricia M., Barber, P. Alan, Levi, Christopher R.

Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation

- Butcher, Kenneth, Christensen, Søren, Fink, John, Tress, Brian, Donnan, Geoffrey A., Davis, Stephen M., Parsons, Mark, De Silva, Deidre A., Ebinger, Martin, Levi, Christopher, Jeerakathil, Thomas, Campbell, Bruce C. V., Barber, P. Alan, Bladin, Christopher

Pretreatment diffusion - and perfusion - MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis

- Parsons, Mark W., Christensen, Soren, Davis, Stephen M., McElduff, Patrick, Levi, Christopher R., Butcher, Ken S., De Silva, Deidre A., Ebinger, Martin, Barber, P. Alan, Bladin, Christopher, Donnan, Geoffrey A.

Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke

- Campbell, Bruce C. V., Christensen, Søren, Donnan, Geoffrey A., Davis, Stephen M., Butcher, Kenneth S., Gordon, Ian, Parsons, Mark W., Desmond, Patricia M., Barber, P. Alan, Levi, Christopher R., Bladin, Christopher F., De Silva, Deidre A.

The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the echoplanar imaging thrombolytic evaluation trial (EPITHET)

- De Silva, Deidre A., Brekenfeld, Caspar, Davis, Stephen M., Ebinger, Martin, Christensen, Søren, Barber, P. Alan, Butcher, Kenneth S., Levi, Christopher R., Parsons, Mark W., Bladin, Christopher F., Donnan, Geoffrey A.

Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)

- De Silva, Deidre A., Fink, John N., Davis, Stephen M., Christensen, Soren, Ebinger, Martin, Bladin, Christopher, Levi, Christopher R., Parsons, Mark, Butcher, Ken, Barber, P. Alan, Donnan, Geoffrey A.

Clinical-diffusion mismatch and benefit from thrombolysis 3 to 6 hours after acute stroke

- Ebinger, Martin, Iwanaga, Takeshi, Donnan, Geoffrey A., Davis, Stephen M., Prosser, Jane F., De Silva, Deidre A., Christensen, Soren, Collins, Marnie, Parsons, Mark W., Levi, Christopher R., Bladin, Christopher F., Barber, P. Alan

Expediting MRI-based proof-of-concept stroke trials using an earlier imaging end point

- Ebinger, Martin, Christensen, Soren, De Silva, Deidre A., Parsons, Mark W., Levi, Christopher R., Butcher, Kenneth S., Bladin, Christopher F., Barber, Alan, Donnan, Geoffrey A., Davis, Stephen M.

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial

- Davis, Stephen M., Donnan, Geoffrey A., Parsons, Mark W., Levi, Christopher, Butcher, Kenneth S., Peeters, Andre, Barber, P. Alan, Bladin, Christopher, De Silva, Deidre A., Byrnes, Graham

EPITHET: where next? Authors' reply

- Davis, Stephen M., Donnan, Geoffrey A., Parsons, Mark W., Levi, Christopher, Butcher, Kenneth S., Barber, P. Alan, Bladin, Christopher, De Silva, Deidre A., Peeters, Andre